The Maguuma Jungle is perhaps the most dangerous place on the continent of Tyria. The Krytans don't often venture inside its borders, and those who do are seldom heard from again. Stories of man-eating plants and gigantic insects are commonly told around the campfires and inside the huts of the local villages; most of the time to scare little children from wandering into its clinging vines.
The quest A Brother's Fury, which can be obtained from Druid's Overlook, leads here. From Druid's Overlook, the most direct path is to head northwest following the road.