You can use the fact that the hex ends after a 3 second delay to inflict spike damage by casting another spell right before it ends. For example with Vapor Blade.
Unlike the similar skills Lightning Surge and Incendiary Bonds, Shatterstone's damage will apply if it ends before 3 seconds are up. Thus, removing the hex is generally pointless. This also makes Shatterstone a particularly strong spike against foes with Natural resistance.
Because of the recharge time it synchronizes particularly well with Glowing Ice, which can be cast quickly enough to benefit from the 3 second hex.